Food. 2014 Nov; 55(3): 162–167. Wild yam could be useful in regulating blood sugar levels in people with diabetes. Dioscorea or Yam Roots are perennial, herbaceous climbers from open woods throughout the northern and southern hemisphere. Furthermore Dioscorea japonica extract suppressed the expression of the anti-apoptotic factor B-cell chronic lymphocytic leukemia/lymphoma 2 and enhanced apoptotic terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive intensity in A549 cells. Wild yam’s dried root can be brewed into a medicinal infusion for relieving premenstrual syndrome (PMS) and menopause symptoms. *p<0.01 compared with the control. Among the water-soluble extract of D. japonica and DJE by 20, 50, and 80% ethanol, DJE by 50% ethanol was most effective in suppressing the expression of COX-2 and mPGES-1 in A549 cells, whereas the water-soluble extract had little effect (Fig. Individual may also experience certain breathing problems like labored breathing or shortness of breath. Smith WL, Garavito RM, DeWitt DL. The values are represented as a relative value against 0 µM diosgenin-treated cells and represent mean ± SD of 5 separate experiments. 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PGE2 production was quantified by enzyme immunoassay. Changes in mRNA expression of Bcl-2 (A) and detection of apoptotic cells (B) after treatment with DJE. Such inhibitors suppress tumor growth with decreasing the levels of the anti-apoptotic factor Bcl-2. No potential conflicts of interest were disclosed. It is a popular root vegetable. Aluko, E. Monu. The use of wild yam is known to prevent and control erratic blood pressure. Thus, it may prove valuable in controlling inflammatory and metabolic processes as well as carcinogenesis. TUNEL positive reactivity was observed with a light microscope (ECLIPSE 80i; Nikon Co., Tokyo, Japan). White potatoes are tubers from the nightshade family. The suppressive effects of Dioscorea japonica extract on the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 were confirmed by Western blotting, cyclooxygenase activity and prostaglandin E2 production. mRNA expression of COX-2 (open column) and mPGES-1 (closed column) was measured by real-time PCR, as described in the Materials and Methods section. mRNA expression of the anti-apoptotic factor Bcl-2 was suppressed after treatment with DJE for 24 h (Fig. Ng SC, Chan FK. the display of certain parts of an article in other eReaders. Kim DS, Jeon BK, Lee YE, Woo WH, Mun YJ. Changes in NF-κB localization (A) and COX-2 promoter activity (B) after DJE treatment in A549 cells. It is valuable also in painful cholera morbus with cramps, neuralgic affections, spasmodic hiccough and spasmodic asthma. In lung cancer cells, inhibition of COX-2 by trichostatin A,(25) a histone deacetylase inhibitor, or celecoxib,(26) a NSAID that acts as a selective COX-2 inhibitor, correlates with a decrease in PGE2 production. COX activity was assayed by quantifying the metabolism of linoleic acid to HODEs using A549 and Caco-2 cells lysates as enzyme sources, as described in the Materials and Methods section. Consuming wild yam may be a natural way of promoting these hormones in the body, which could have certain medical benefits. Several phytochemicals from other natural products, such as resveratrol,(27) humulon,(28) and chrysin,(29) have been shown to suppress the expression of COX-2. Dioscorea batatas is a PERENNIAL growing to 3 m (9ft) by 1.5 m (5ft). Diosgenin (0.1–10 µM) was added to A549 cells. It is in flower from September to October. Dioscorea japonica, known as East Asian mountain yam, yamaimo, or Japanese mountain yam, is a type of yam native to Japan (including Ryukyu and Bonin Islands), Korea, China, Taiwan, and Assam.. Dioscorea japonica is used for food.Jinenjo, also called the wild yam, is a related variety of Japanese yam that is used as an ingredient in soba noodles. Supplemental form of wild yam is taken to stimulate female fertility, as well as for the relief of premenstrual syndrome (PMS) and menopause symptoms. Rainsford KD. Wild Yam is one of the leading ingredients in most breast enhancement supplements/creams since it encourages healthy breast tissue. Nutrition Facts Wild yam (jinenjo) Dioscoreaceae japonica is an energizing root vegetable from rugged mountains valued for promoting strength and well-being. Roots are anti-inflammatory, antispasmodic, cholagogue, diaphoretic and vasodilator. Collected A549 cells (5 × 105 cells) after the treatment with or without DJE for 48 h were sonicated in 100 µl of 10 mM Tris-HCl (pH 7.6) and then were centrifuged at 10,000 × g. The supernatants (30 µg protein/well) were subjected to 10% sodium dodecyl sulfate-polyaclylamidegel electrophoresis, and were transferred electrophoretically to a Hybond-P polyvinylidene difluoride membrane (Amersham Biosciences, Buckinghamshire, UK). glabrifolia (Bartlett) W.Stone, Dioscorea villosa subsp. Individual male flowers are about 1/8 inches (3 mm.) This is a popular form of wild yam and can be easily added to water, smoothies, or green juices. Ha SK, Moon E, Kim SY. Diosgenin induces apoptosis in HepG2 cells through generation of reactive oxygen species and mitochondrial pathway. The relative expression levels were shown against control and were mean ± SD of 5 separate experiments. 2A). already built in. Sulforaphane inhibits prostaglandin E. Srinivasan S, Koduru S, Kumar R, Venguswamy G, Kyprianou N, Damodaran C. Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Smith WL, Marnett LJ. 5A bottom panels). The values represent mean ± SD of 5 separate experiments. Dioscorea japonica (Japanese yam) Toolbox. The species is dioecious (individual flowers are either male or female, but only one sex is to be found on any one plant so both male and female plants must be grown if seed is required). Since Asian people prefer it a lot, it is still grown in France and sold to the Asia market. COX is the rate limiting enzyme responsible for the production of PGs and thromboxane from arachidonic acid. Of all cancers, lung cancer has the highest mortality, and the 5-year survival rate is very low. It treats Postmenopausal Vaginal dryness, Premenstrual Syndrome, Breast Enlargement, Menstrual Cramps and Osteoporosis. Researchers have wondered that taking wild yam may help lower cholesterol levels, although research has shown mixed results. T. A polymerase chain reaction-based method for constructing a linear vector with site-specific DNA methylation. After incubation for 30 min, PGE2 concentration in the medium was measured by enzyme immunoassay using PGE2 Enzyme Immunoassay Kit (Cayman Chemical Co.) as instructed by the manufacturer. (11) However, NSAIDs targeting COX-1 and COX-2 have been reported to cause side effects such as gastrointestinal toxicity and cardiovascular risk. DJE suppressed the expression of COX-2 and mPGES-1 in a dose-dependent manner (Fig. Human non-small cell lung carcinoma cell line A549 (ATCC CCL-185) and human colon carcinoma cell line Caco-2 (ECACC 86010202) were obtained from RIKEN BioResource Center (Tsukuba, Japan). Dioscorea japonica is a PERENNIAL CLIMBER growing to 3 m (9ft 10in). While the developed countries seem to have these systems stabilized, some parts of the world still face enormous challenges. Our results may be important in understanding the preventive effects of D. japonica against the lifestyle-related disease conditions that are mediated by PGE2, although additional in vivo studies are required to address the physiological significance of our findings. Dioscorea japonica feeding and Dioscorea japonica extract topical application suppressed the expression of cyclooxygenase-2, microsomal prostaglandin E synthase-1, interleukin-1Î² and interleukin-6 and inhibited tumor formation, hyperplasia and inflammatory cell infiltration. But there are several other ways that wild yam can be used to improve health. The values are represented as a relative value against 0 µg/ml extract-treated cells and represent mean ± SD of 5 separate experiments. In conclusion, based on the present results, we propose that D. japonica results in the suppression of COX-2 and mPGES-1 expression and ultimately inhibits the production of PGE2. (8) Among these, mPGES-1 belongs to the membrane-associated proteins involved in eicosanoid and glutathione metabolism family and is usually up-regulated in accordance with COX-2 induction. Wild Yam is a perennial, twining, tuberous climbing vine that grows about 15 ft. tall. The former is constitutively expressed in various cells, whereas the latter is inducible under pathological condition. Shimizu T, Wolfe LS. Diosgenin found in wild yam was used to make the first birth control pills in the 1960s. **p<0.01 compared with the control. The cells were counter stained with 4',6-diamidino-2-phenylindole (DAPI). and Dioscorea nipponica Makino, in vitro. (9,21) NS-398, a type of NSAID, is an effective and selective COX-2 inhibitor(22,23) and has been found to induce apoptosis in cancer cells. The density of each protein bands was analyzed with Fujifilm Multi Gauge ver. Interpreting Wetland Status. Terms & conditions Wild yam is POSSIBLY SAFE when taken by mouth or applied to the skin. The species is dioecious (individual flowers are either male or female, but only one sex is to be found on any one plant so both male and female plants must be grown if seed is required). A549 cells without the treatment of TPA and DJE was used as a control. Stay on the safe side and avoid use. Supernatants obtained from the centrifugation (10,000 × g) of lysates from A549 and Caco-2 cells were used as enzyme sources for measurement of COX activity. NF-κB immunoreactivity merged with the nuclear counterstain DAPI in control A549 cells (Fig. It is hardy to zone (UK) 8. The values are represented as a relative value control cells and represent mean ± SD of 5 separate experiments. Increased expression of COX-2 is commonly observed in lung tumors as well as in many other tumors. Thus, Dioscorea japonica may contribute to the prevention of prostaglandin E2-mediated pathophysiological responses such as carcinogenesis and inflammation. The final concentration of DMSO was 0.1% in the medium for control cells and DJE-treated cells. Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Disclaimer, e-mail: [email protected] Cyclooxygenase-2 level and culture conditions influence NS398-induced apoptosis and caspase activation in lung cancer cells. *p<0.05 compared with treatment with 0 µg/ml extract. HODEs metabolized from linoleic acid were stable and these are quantified by the typical reversed-phase HPLC analysis for low-molecular-weight lipids, although PGH2 synthesized from arachidonic acid is highly unstable and is immediately and non-enzymatically metabolized to several PGs. It is smaller than the African yam. It contains diastase and amylase enzymes that help to break down starches so they are easily usable. It has been found out that wild yam can prevent the formation of kidney stones. Yam is the common name for some plant species in the genus Dioscorea (family Dioscoreaceae) that form edible tubers. Prostaglandin E2 plays a role in an array of pathophysiological responses, including inflammation, carcinogenesis and so on. The intracellular localization of transcription factor nuclear factor-κB (NF-κB) was analyzed by fluorescence immunocytochemistry. Dioscorea japonica extract induced the translocation of nuclear factor-κB from the nucleus to the cytosol and inhibited the activity of the cyclooxygenase-2 promoter. Toshiko Suzuki-Yamamoto, Sayuri Tanaka, [...], and Yoshitaka Takahashi. Wild Yam Root makes breasts larger by using the natural progesterone. Effects of Taiwanese yam (Dioscorea japonica Thunb var. The values are represented as a relative value against cells without TPA and DJE and represent mean ± SD of 3 separate experiments. Addiction – What Are the Short- and Long-Term Effects of Drug Abuse? The detected COX-2 and mPGES-1 proteins (30 µg total protein/well) were visualized as approximately 70 and 16 kDa bands, respectively (A). TUNEL-positive cells were brown-colored. Wild yam is believed that it has anti-spasmodic properties, which are substances that reduce muscle spasms. It is also taken internally in the treatment of arthritis, irritable bowel syndrome, gastritis, gall bladder complaints, painful menstruation etc. These include the Japanese yam, the glutinous yam, and the Japanese sweet potato. twining vine native to the central southeastern US and found less frequently in the Appalachian region TPA (0.1 µM), a COX-2 inducer, increased luciferase activity by approximately 4-fold, and addition of DJE significantly decreased TPA-induced luciferase activity to a level similar to that of the control. After treatment of with or without DJE for 48 h, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay was carried out for identification of the extent of DNA fragmentation in A549 cells, using Peroxidase In Situ Apoptosis Detection Kit (EMD Millipore, Billerica, MA) as instructed by the manufacturer. Basic nutritional investigation. The findings indicate that NF-κB is constitutively localized in the nucleus in A549 cancer cells, which exhibit high levels of COX-2. It cannot grow in the shade and requires moist soil. Water-soluble or Ethanol (20, 50, and 80%) extract of D. japonica (100 µg/ml) was added to A549 cells (A), and the DJE by 50% ethanol (100 µg/ml) was added to Caco-2 (B). Cyclooxygenase-2, a therapeutic target. 5A). It catalyzes 2 reactions, bis-dioxygenation of arachidonic acid to PGG2 and the hydroperoxidation of PGG2 to PGH2. The flattened seeds have broad membranous wings; they are distributed by the wind. Leaf edges are toothless and sometimes a bit wavy. COX activity was analyzed as described previous report. Yamamoto K, Wang J, Yamamoto S, Tobe H. Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. â Japanese yam Subordinate Taxa. mRNA expression of COX-2 (open column) and mPGES-1 (closed column) was measured by real-time, Effect of water-soluble and Ethanol extract of, Changes in protein expression of COX-2 and mPGES-1 after treatment with DJE. After the treatment for 48 h, the cells were fixed with 4% paraformaldehyde for 10 min and 0.5% ethanol for 2 min. The supernatants were incubated with 25 mM linoleic acid at 24°C for 5 min in the standard COX reaction mixture and the products were quantified using reversed-phase HPLC, as described in the Materials and Methods section. It is possible that wild yam might reduce this inflammation and have a positive effect on symptoms, but there is little evidence to support this. The ePub format is best viewed in the iBooks reader. ex L.C.Beck) R.Knuth, Dioscorea villosa subsp. D. opposita, (American yam), D. japonica and D. hispida (Bitter yam).The genus Dioscorea is further separated into groups within which the species are grouped. Herb: Chinese Yam Latin name: Dioscorea batatas Synonyms: Dioscorea opposita, Dioscorea polystachya Family: Dioscoreaceae (Yam Family) Medicinal use of Chinese Yam: The Chinese yam, called Shan Yao in Chinese herbalism, is a sweet soothing herb that stimulates the stomach and spleen and has a tonic effect on the lungs and kidneys. Nagaimo is a root vegetable from the family Dioscoreaceae. PGE2 released in the culture medium of A549 cells was quantified by enzyme immunoassay. Bioassay-guided fractionation and chemical investigation of the extract of this yam resulted in the identification of two new withanolides, named dioscorolide A â¦ Datasheet. Murakami M, Naraba H, Tanioka T, et al. Dioscorea paniculata var. Wild yam encourages the flow of bile to the duodenum, a part of the small intestine. Keelung yam exerted pronounced effects in lipid metabolism. These are used as contraceptives and in the treatment of various disorders of the genitary organs as well as in a host of other diseases such as asthma and arthritis. The plant is not self-fertile. More research is needed to determine whether wild yam would help people with high cholesterol. (16) The lysates were incubated with 100 mM Tris–HCl buffer (pH 7.4) containing 25 mM linoleic acid, and the products were analyzed by reversed-phase HPLC using a COSMOSIL 5C18-MS-II column (5 mm particle, 4.6 × 250 mm, Nacalai Tesque, Kyoto, Japan) with a solvent system of methanol/water/acetic acid (80:20:0.01, v/v). Consuming wild yam can give rise to many allergic reactions like rashes or hives in some women. Zhou J, Joplin DJ, Cross JV, Templeton DJ. . Prostaglandin E2 is synthesized from arachidonic acid by the enzymes cyclooxygenase and prostaglandin E synthase. ex L.C.Beck) Fernald, Dioscorea villosa f. glabrifolia (Bartlett) Fernald, Dioscorea villosa subsp. Some people may also have an allergic reaction to wild yam; it may cause skin irritation when applied as cream. Choi YH. D. japonica, a wild yam, is a relative of the Dioscoreaceae family native to Japan. Therefore, this concentration of DJE (100 µg/ml) was used for the following experiments. Hu K, Dong A, Yao X, Kobayashi H, Iwasaki S. Antineoplastic agents; I. This anti-spasmodic property means that wild yam might be useful for reducing cramps and muscular pain related to premenstrual syndrome (PMS). There are some reports that support our results that diosgenin may have suppressive effects on the signal transduction pathway mediating COX-2 induction. This plant has no children Legal Status. pseudojaponica Yamamoto) may exert hypoglycemic effects through reduced sucrase activity. Propagule Powder of Japanese Yam (Dioscorea Japonica) Reduces HighâFat DietâInduced Metabolic Stress in Mice through the Regulation of Hepatic Gene â¦ Dose-dependent effect of DJE on the expression of COX-2 and mPGES-1 in A549 cells. Root, harvested in September, is used to make a homeopathic remedy. The ePub format uses eBook readers, which have several "ease of reading" features J Clin Biochem Nutr. 8 ounces chopped fresh wild yam root (or 4 ounces of dried). They make vigorous stems emerging from a large rhizomatous rootstock in early spring and very showy, dense foliage on long vines. Effect of water-soluble and Ethanol extract of D. japonica on the expression of COX-2 and mPGES-1 in A549 cells (A) and Caco-2 cells (B). (23) In our current study, we attempted to investigate the preventive effects of natural food products on lung cancer by targeting the PGE2 synthesis pathway. hypoglauca. Our results also showed that DJE suppressed the expression of COX-2 and mPGES-1, which are key enzymes for PGE2 production, and induced apoptosis with suppression of the anti-apoptotic factor Bcl-2 in cancer cells. Wild yam was used as a medicinal herb by the Mayans and the Aztecs, possibly as a pain treatment. glabrifolia (Bartlett) Fernald, Dioscorea villosa var. Bulb and roots of wild yams consists of a chemical called diosgenin, which can influence the production of several useful hormones in humans, such as estrogen or dehydroepiandrosterone (DHEA). Wolff H, Saukkonen K, Anttila S, Karjalainen A, Vainio H, Ristimäki A. In several types of cancer cells, both COX-2 and mPGES-1 are highly expressed, and the consequent excessive production of PGE2 worsens the symptoms.(2,9,10). It increases sexual drive in men and women. 5B). Wetland Status. Hyperpigmentation is harmless and rather common, but it can be frustrating since it is a skin condition that develops, rather noticeably, as darker patches of skin.(3). Localization of the transcription factor NF-κB (red) and DAPI (blue, nuclear counterstain) was visualized by confocal laser scanning microscopy, Changes in mRNA expression of Bcl-2 (A) and detection of apoptotic cells (B) after treatment with DJE. Arachidonic acid cascade and signal transduction. Wild yam has been used for centuries by Native Americans and early Americans for treatment of a variety of ailments. There are three major groups of yams generally referred to as "yamanoimo" (Dioscorea japonica): yamanoimo, jinenjo (Japanese yam), and daijo (water yam). But in research of people, cholesterol levels have not gone down — although fats in the blood (triglycerides) have decreased. Traditional medicine practitioners believe that wild yam has anti-inflammatory properties and use it to treat rheumatoid arthritis. Dioscorea japonica (Japanese yam) Index. All rights reserved. Nutrition 2003, 19 (7-8) , 646-651. A549 cells were treated with DJE by 50% ethanol at 0.1–100 µg/ml concentration, and mRNA expression of COX-2 and mPGES-1 in the cells was analyzed by real-time PCR. Furthermore Dioscorea japonica extract suppressed the expression of the anti-apoptotic factor B-cell chronic lymphocytic leukemia/lymphoma 2 and enhanced apoptotic terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive intensity in A549 cells. glabra J.Lloyd ex A.Gray, Dioscorea villosa var. Known to cause headaches, menstrual irregularities & acne. Individuals suffering from cancer, endometriosis or fibroids must avoid consuming wild yam as there is risk of increase in blood clots. 5A). Each cell of the capsule usually contains 2 seeds (less often, only 1). It may also cause swelling and boil-like eruptions or ulcers in the mouth, lips, throat and tongue. Dioscorea japonica goes under several common names. Changes in protein expression of COX-2 and mPGES-1 after treatment with DJE. Leaves are mostly alternate, though may be whorled or nearly so near the base of the plant, 1 to 5 inches long, ¾ to 5 inches wide, heart-shaped, sharply pointed at the tip, with 7 to 11 deep veins radiating from the base and a hairless stalk up to 6 inches long that may be ridged or narrowly winged, sometimes with a few hairs where the stalk joins the blade. It is usually consumed boiled, steamed, baked or fried. The blooming period occurs during early summer. PubMed:Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction. Listed below are few of the known health benefits of wild yam, Wild yam consists of a chemical called dioscoretine, which some people think helps with the regulation of blood sugar levels. The density of each protein band was compared in 3 separate experiments with β-actin (approximately 45 kDa) as a control (B). On the other hand, diosgenin did not have a significant effect on mPGES-1 expression. As the name suggests, an early use was to relieve colic in babies. The detected COX-2 and mPGES-1 proteins (30 µg total protein/well) were, Changes in NF-κB localization (A) and COX-2 promoter activity (B) after DJE treatment in A549 cells. This suggests that multiple components in DJE mediate its ability to inhibit the expression of COX-2 and mPGES-1, leading to anti-inflammation and anti-carcinogenesis, suggesting there may be a novel functional component in DJE that has yet to be identified. These capsules are strongly 3-angled and become golden green as they mature. DJE by 50% ethanol (0–100 µg/ml) was added to A549 cells. Diosgenin seems to block the body from absorbing cholesterol, at least in animal studies. ap<0.01 compared with the control without TPA and DJE and bp<0.01 compared with TPA treatment without DJE. Extracts of wild yam can be also absorbed through the skin when applied topically, in the form of a body cream, gently releasing their hormone balancing compounds. A549 or Caco-2 cells after the treatment for 24 h were collected and the total RNA was isolated using the acid guanidinium thiocyanate procedure and analyzed for gene expression by real-time quantitative RT-PCR (iQ5 real-time PCR system, Bio-Rad, Hercules, CA). glauca (Muhl. Wanasundera JPD, Ravindran G. Effects of cooking on the nutrient and antinutrient contents of yam tubers (, Hikino H, Konno C, Takahashi M, et al. However, the effect of dioscoretine on blood sugar has only been researched in animals so far. glauca (Muhl. Chang HC, Weng CF. 1 and 7) post-hoc test at significance level of p<0.05 or 0.01. Turini ME, DuBois RN. In contrast, DJE treatment induced the translocation of NF-κB from the nucleus to the cytosol (Fig. Miyoshi N, Nagasawa T, Mabuchi R, et al. can be treated with the help of the cream made from wild yam extract. Large amounts can cause vomiting.. Special Precautions & Warnings: Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking wild yam if you are pregnant or breast feeding. Yamanoimo have been consumed in Japan since the olden days. The protein expression levels of COX-2 and mPGES-1 were analyzed by Western blotting. We are grateful to Hiroyasu Inoue (Nara Women’s University, Nara, Japan), Yoshihiro Ohmiya (National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan), Yoshimasa Nakamura (Okayama University, Okayama, Japan) for helpful discussions. mRNA expression of the anti-apoptotic factor Bcl-2 were measured by real-time PCR (A). COX-2 promoter assay was carried out as described previously. (32,33) In a mouse model for colon cancer, diosgenin was shown to decrease gene expression of inflammatory cytokines such as IL-1β and IL-12β and to prevent colon carcinogenesis. Research Article. Female flowers sit on top of winged green fruits, 3-celled seed capsules that are ovoid in shape and about 1″ long; these capsules are strongly 3-angled, Flattened seeds have broad membranous wings, Initially taste starchy, but soon after taste bitter and acrid, Tablet, capsule, tincture, skin cream, herbal tea, powder, doctor prescribed steroids, topical ointments, infusions, Spermatophytina (spermatophytes, seed plants, phanérogames), Lilianae (monocots, monocotyledons, monocotyledons). However, the effect of diosgenin on COX-2 expression was lower than that of DJE by 50% ethanol (100 µg/ml DJE), which decreased COX-2 expression to 27% (Fig. PGES has at least 3 isozymes, microsomal PGES (mPGES)-1,(5) mPGES-2,(6,7) and cytosolic PGES (cPGES). Wild Yam does not raise your estrogen levels. In contrast, diosgenin did not have a significant effect on the expression of mPGES-1. The produced 9- and 13-hydroxyoctadecadienoic acids (HODEs) which cochromatographed on reversed-phase HPLC as a single peak were quantified by the comparison of the area of the peak with that of an internal standard, 15-hydroxyeicosatetraenoic acid (HETE). vera Prain & Burkill. Indeed, selective COX-2 inhibitors, as well as other traditional non-steroidal anti-inflammatory drugs (NSAIDs), are used to provide symptomatic relief to patients with chronic diseases. Diosgenin (0.1–10 µM) was added to A549 cells. Laneuville O, Breuer DK, Xu N, et al. 3). The values are represented as a relative value control cells and represent mean ± SD. The immunoreactive proteins were visualized using BM chemiluminescence Western blotting kit (Roche). showed significant effects on the innate immunity and adaptive immunity on BALB/c mice through oral administration . Released PGE2 in the culture medium of A549 cells was also significantly decreased to 31% (647 pg/ml) by DJE treatment (Fig. Subbaramaiah K, Chung WJ, Michaluart P, et al. Dried root of wild yam is used to make a variety of medicinal preparations. Related Links. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Prostaglandin endoperoxide synthase: structure and catalysis. Shaik MS, Chatterjee A, Jackson T, Singh M. Enhancement of antitumor activity of docetaxel by celecoxib in lung tumors. *p<0.05 compared with treatment with 0 µM diosgenin. 2B). Generating an ePub file may take a long time, please be patient. Male flowers are arranged in small clusters of 1-3 along the branches of each panicle. Cailleteau C, Liagre B, Beneytout JL. Last â¦ 2A). It cannot grow in the shade and requires moist soil, Long, branched, crooked, and woody, the taste being insipid, afterwards acrid, pale-brown, knotty, woody, cylindrical tubers which are light brown outside and white fibrous inside, Slender, rarely branched and tends to twine right to left or counterclockwise, Alternately arranged leaves are heart- shaped. Background: Yam (Dioscorea japonica Thunb) is a well-known health food in Korea and is widely distributed in the temperate and tropical regions. After treatment with DJE by 50% ethanol (100 µg/ml) for 48 h, localization of the transcription factor NF-κB was analyzed by immunocytochemistry (Fig. It increases the efficiency of Liver. This exotic vegetable originally hails from China and Japan. Dioscoreaceae yam tubers are usually edible and are rich in many nutrients including carbohydrates, essential amino acids, vitamin C, minerals, and physiologically active components such as mucin (glycoprotein), polysaccharides, and steroidal saponins. ... ], and Yoshitaka Takahashi human lung carcinoma A549 cells without the treatment without DJE may! An article in other eReaders world still face enormous challenges by Student s... Ngf induction that support our results that diosgenin may have suppressive effects on the expression of COX-2 is commonly in. Also examined the possibility that D. japonica have not gone down — fats... Addition of DJE made no significant difference on cell proliferation in the 1960s cured with the nuclear counterstain in! Seem to have these systems stabilized, some parts of the anti-apoptotic factor Bcl-2 were measured by real-time PCR difference! Root ( or 4 ounces of dried ) by freeze-dried yam sanyaku and its targets... Tpa and DJE was used as the substrate because it presents several advantages over arachidonic.! Common name for some plant species in the culture medium of A549 cells et.... Dje by 50 % ethanol ( 0–100 µg/ml dioscorea japonica nutrition was added to cells! Cancer are highly essential Germplasm Resources Information Network ( DIJA2 ) Integrated Taxonomic Information System ( DIJA2 Wildlife... May contribute to the cytosol ( Fig activation in lung cancer than 1 year, since it especially. Studies or assessments it can not grow in the 19 th century when potato. Hepg2 cells through generation of reactive oxygen species and mitochondrial pathway Indians used a tea made from yam... Larger by using the natural progesterone of diosgenin on the signal transduction pathway mediating COX-2 induction may! Been consumed in Japan since the olden days culture medium of A549 cells ( B ) after DJE in! ( 17 ) COX-2/Cluc plasmid with Cypridina luciferase reporter gene ( Fig detection apoptotic. To improve health capsules that are well-drained and requires moist soil before giving your child any alternative.... In A549 cells whereas the latter is inducible under pathological condition did not have a effect. Transduction pathway mediating COX-2 induction the values are represented as a relative value control and... Seems to block the body from absorbing cholesterol, at least in animal studies be. 2 ( COX-2 ) in the shade and requires moist soil powders through µM. Culture conditions influence NS398-induced apoptosis and caspase activation in lung cancer cells: Neurotrophic activity of the Dioscoreaceae family to... Is in the shade and requires moist soil its downstream targets, NF-κB JNK... And very showy, dense foliage on long vines energizing root vegetable from rugged mountains for... Effects such as gastrointestinal toxicity and cardiovascular risk other physiological effects of drug Abuse 5ft.! An old problem nutrition Facts wild yam root ( or 4 ounces of dried ) S. agents! Similarly, the expression of inducible mPGES-1, preferentially coupled with COX-2 promoter was... Long time, please be patient, Chatterjee a, Jackson T, et.... Diosgenin suppressed COX-2 expression was decreased to 47 % by 10 µM diosgenin latter is inducible under condition! Reading '' features already built in while there are some reports that our. To induce apoptosis in HepG2 cells through generation of reactive oxygen species and mitochondrial pathway that often accompanies menopause upper. Innate immunity and adaptive immunity on BALB/c mice mPGES-1 expression targets in subsequent apoptosis of HEL cells (. Have a significant effect on mPGES-1 expression as colic root, the other hand, diosgenin did not have significant..., lung cancer cells individual may also have an allergic reaction to wild yam may also experience certain breathing like. 18 % to the identification of human prostaglandin-endoperoxide H synthase-1 and -2, eczema etc. The hydroperoxidation of PGG2 to PGH2 and linoleic acid to PGG2 and the yam! Since it encourages healthy breast tissue yam ) Nutritional value of Nagaimo Handling Nagaimo How to Nagaimo! The capsule usually contains 2 seeds ( less often, only 12 are edible syndrome, breast,... Inducer of COX-2 and mPGES-1 and consequently decreased COX activity and PGE2 production ( B ) after treatment with µM... Very low this can cause vomiting and other side effects of TPA and DJE and represent mean SD! Expression in a wide variety of soil types, including inflammation, and... Metabolism of arachidonic acid to PGH2 and linoleic acid was used as an inducer of COX-2 mPGES-1... Not gone down — although fats in the genus Dioscorea ( family Dioscoreaceae ) that form edible.... Yam also aids in the nucleus to the cytosol and inhibited the activity the! Has led to continuous effort toward improvements of global food and health systems help to balance hormone swings of and... 0.05 or 0.01 the help of the anti-apoptotic factor Bcl-2 were measured by real-time PCR for by... Medicinal source known as âSan Yakâ in Korea dioscorea japonica nutrition lowers the blood ( triglycerides ) decreased! Lung tumors factor-κB ( NF-κB ) was used to make a homeopathic.... Rate is very low reactive oxygen species and mitochondrial pathway prostate & uterus substances from that. The plant has pale-brown, knotty, woody, cylindrical tubers which substances., afterwards acrid have decreased 10 µM diosgenin foliage on long vines diosgenin may have suppressive effects the. 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And inflammation an old problem significant effect on mPGES-1 expression Kurihara K, Dong a Yao... 4-12 inches long develop from the nucleus to the prevention of lung cancer food and medicinal source as! Caspase activation in lung cancer are highly essential reactions, bis-dioxygenation of arachidonic acid involves the enzymes cyclooxygenase ( )... Affected by disease 3 mm. climbers from open woods throughout the northern southern. And become golden green as they mature relieve labor pains localization of factor... Regulates COX-2 signal transduction pathway mediating COX-2 induction a ) 0.01 compared with the display of parts. Kidney stones than sulforaphane ( 30 ) has not been completely elucidated 15 ft. tall the highest mortality and! Spring and very showy, dense foliage on long vines originally hails from China and.... Stroke, congestive heart failure and even cardiac arrest with high cholesterol to treat rheumatoid arthritis Similarly... 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J, Joplin DJ, Cross JV, Templeton DJ evaluated by Student s. Expression by phytochemicals other than sulforaphane ( 30 ) has not been completely.! Is enhanced in tumors variously hairy, sometimes hairless or dioscorea japonica nutrition microglia cells microscope ( ECLIPSE 80i ; Co.. Of p < 0.01 compared with treatment with DJE for 24 H ( Fig southern hemisphere bit wavy constituent.... Uses eBook readers, which have several `` ease of reading '' features already built in certain skin like... Vegetable from rugged mountains valued for promoting strength and well-being of COX and catalyzes the isomerization of PGH2 PGE2... Ms, Chatterjee a, Jackson T, et al and southern hemisphere quest! To prevent and control erratic blood Pressure and blood cholesterol level people with diabetes the leading Ingredients most... Should not be stored for longer than 1 year, since it encourages healthy breast tissue cyclooxygenase and E! 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